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KMID : 1123920090230030662
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 3 p.662 ~ p.672
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Effects of Mixed Medicinal Herbs on Altering Body Weight and Lipid Profiles in Rats Fed High-fat Diet
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Ju Jin-Man
Kim Mi-Rye
Suk Jang-Mi
Lee Young-Sun
Park Jong-Hyun
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Abstract
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Obesity has increased dramatically increased in recent days. It has resulted in obesity-associated diseases and metabolic syndromes including hyperlipidemia, diabetes and cardiovascular diseases. Our study was investigated to determine the antiobese effects of mixed 2 medicinal herbs (AR+AC) in rats fed high-fat diet with an abundance of carbohydrates. Two groups of male Sprague-Dawley rats were fed different diets during 8 weeks: normal diet containing 5% corn oil (w/w), high-fat diet containing 10% (w/w) lard plus 5% (w/w) corn oil (HF). And High-fat diet group was treated with saline or 100 mg/kg ARAC or 300 mg/kg ARAC (PO). Antiobese effect was evaluated by measuring the changes of body weight, adipose tissues weight. Also we examined levels of leptin, adiponectin and lipid profiles in serum. Finally we compared morphological change in adipocytes and hepatocytes between HF and ARAC group. Mixed combination of 2 medicinal herbs, but not alone, caused significant decrease in body weight, organ weight (liver, epididymal fat, and BAT) compared with control HF group. The ARAC group had markedly lower serum levels of adiponectin when compared with HF group. Also the epididymal white adipocyte size of ARAC group were diminished comparing to the HF group. These results suggest that the possibility of ARAC combination, as an antiobese formula, by suppression of body weight gain and increased lipid profiles.
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KEYWORD
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mixed medicinal herbs, antiobese, high-fat diet, body weight, lipid profile, adipose tissue
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